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Download high-resolution microsoft AVI file versions of the movies playing here by following the [AVI File] links. The legends below also provide citations and links to Smithlab publications that will provide experimental details and discussion pertaining to these movies. Please use these movies in any way you like, but kindly acknowlege the authors of the corresponding publication when using them in public venues.
Note that most of these AVI files are quite large and may take a while to download. Your browser may default to automatically play these movies with its media player, but you should also be able to save them locally.
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Dendrite Growth in vivo, 600:1 Time-Lapse,
3-Day Zebrafish Larva.
Niell, C.M., Meyer, M.P and Smith, S.J (2004)
In vivo imaging of synapse formation on a growing dendritic arbor. Nature Neurosci. 7: 254-260. [PDF]
5.8 MB High Res [AVI File]
494 KB [Quicktime Zip File]
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Dendrite Growth & PSD Punctum Formation in vivo,
3-Day Zebrafish Larva (PSD95-GFP label).
Niell, C.M., Meyer, M.P and Smith, S.J (2004)
In vivo imaging of synapse formation on a growing dendritic arbor. Nature Neurosci. 7: 254-260. [PDF]
17.9 MB High Res [AVI File]
4.5 MB [Quicktime Zip File]
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Retinal Ganglion Cell Axon Arbor Growth in vivo,
4-Day Zebrafish Larva (VAMP-GFP label).
Hua, Y., Smear, M.C., Baier, H. and Smith, S.J (2005) Activity-Based Competition Regulates Axon Growth in Vivo. Nature 434: 1022-1026. [PDF]
5.3 MB High Res [AVI File]
1 MB [Quicktime Zip File]
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Retinal Ganglion Cell Axon Arbor Growth in vivo,
3-Day Zebrafish Larva.
Meyer, M.P. & Smith, S.J (2006) Evidence from in vivo imaging that synaptogenesis guides the growth and branching of axonal arbors by two distinct mechanisms. J. Neurosci. 26:3604-14. [PDF]
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Retinal Ganglion Cell Axon Arbor Growth in vivo,
3-Day Zebrafish Larva.
Meyer, M.P. & Smith, S.J (2006) Evidence from in vivo imaging that synaptogenesis guides the growth and branching of axonal arbors by two distinct mechanisms.
J. Neurosci. 26:3604-14. [PDF]
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Serial Planar Immunofluorescence Mouse Cortex:
Tubulin (Green); Synapsin I (Red)
Preliminary Data, Kristina Micheva (2006)
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Serial Planar Immunofluorescence Mouse Cortex:
Tubulin (Green)
Preliminary Data, Kristina Micheva (2006)
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Aplysia bag cell growth cone,
low magnification.
Forscher, P. and Smith, S.J. (1988) Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107: 1505-1516. [PDF]
20.7 MB High Res [AVI File]
11 MB [Quicktime Zip File]
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Aplysia bag cell growth cone,
high magnification.
Forscher, P. and Smith, S.J. (1988) Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107: 1505-1516. [PDF]
26.9 MB High Res [AVI File]
7.5 MB [Quicktime Zip File]
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Effect of cytochalasin B on Aplysia growth cone,
low magnification.
Forscher, P. and Smith, S.J. (1988) Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107: 1505-1516. [PDF]
31.5 MB High Res [AVI File]
27.8 MB [Quicktime Zip File]
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Effect of cytochalasin B on Aplysia growth cone,
high magnification.
Forscher, P. and Smith, S.J. (1988) Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107: 1505-1516. [PDF]
24.1 MB High Res [AVI File]
20 MB [Quicktime Zip File]
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Actin transport of surface-adhering styrene beads,
Aplysia bag cell growth cone.
Forscher, P. and Smith, S.J (1989) Cytoplasmic actin filaments move particles on the surface of a neuronal growth cone. In: Optical Microscopy for Biology (K. Jacobson and Brian Hermann, Eds.), Wiley-Liss, N.Y. pp. 459-471.
21.8 MB High Res [AVI File]
14.7 MB [Quicktime Zip File]
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Cytochalasin B effect on bead transport,
Aplysia bag cell growth cone.
Forscher, P. and Smith, S.J (1989) Cytoplasmic actin filaments move particles on the surface of a neuronal growth cone. In: Optical Microscopy for Biology (K. Jacobson and Brian Hermann, Eds.), Wiley-Liss, N.Y. pp. 459-471.
20.0 MB High Res [AVI File]
14.5 MB [Quicktime Zip File]
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Glutamate-induced Ca waves,
isolated rat hippocampal astrocyte.
Cornell-Bell, A.H., Finkbeiner, S.M., Cooper, M.S. and Smith, S.J (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signalling. Science 247: 470-473. [PDF]
0.9 MB High Res [AVI File]
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Glutamate-induced Ca waves,
sparse culture of rat hippocampal astrocytes.
Cornell-Bell, A.H., Finkbeiner, S.M., Cooper, M.S. and Smith, S.J (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signalling. Science 247: 470-473. [PDF]
4.9 MB High Res [AVI File]
2.9 MB [Quicktime Zip File]
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Glutamate-induced Ca waves,
dense culture of rat hippocampal astrocytes.
Cornell-Bell, A.H., Finkbeiner, S.M., Cooper, M.S. and Smith, S.J (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signalling. Science 247: 470-473. [PDF]
12.6 MB High Res [AVI File]
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Spontaneous Ca waves,
Rat hippocampal slice culture.
Dani, J.W., Chernjavsky, A., and Smith, S.J. (1992) Neuronal activity triggers Ca waves in hippocampal astrocyte networks. Neuron 8: 429-440. [PDF]
12.4 MB High Res [AVI File]
11.1 MB [Quicktime Zip File]
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Ca waves induced by mossy-fiber tract stimulation,
Rat hippocampal slice culture.
Dani, J.W., Chernjavsky, A., and Smith, S.J. (1992) Neuronal activity triggers Ca waves in hippocampal astrocyte networks. Neuron 8: 429-440. [PDF]
29.2 MB High Res [AVI File]
12.6 MB [Quicktime Zip File]
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Glutamate-induced sprouting of dendritic filopodia,
Rat hippocampal cell culture, low magnification.
Smith, S.J and Jahr, C.E. (1992) Rapid induction of filopodial sprouting by applications of glutamate to hippocampal neurons. In: The Nerve Growth Cone, (P.C. Letourneau, S.B. Kater and E.R. Macagno, Eds.), Raven Press, New York. pp. 19-26. [PDF]
28.0 MB High Res [AVI File]
17.8 MB [Quicktime Zip File]
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Glutamate-induced sprouting of dendritic filopodia,
Rat hippocampal cell culture, high magnification.
Smith, S.J and Jahr, C.E. (1992) Rapid induction of filopodial sprouting by applications of glutamate to hippocampal neurons. In: The Nerve Growth Cone, (P.C. Letourneau, S.B. Kater and E.R. Macagno, Eds.), Raven Press, New York. pp. 19-26. [PDF]
5.8 MB High Res [AVI File]
4.4 MB [Quicktime Zip File]
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Localization of presynaptic Ca influx,
Squid giant synapse, low magnification.
Smith, S.J, Buchanan, J., Osses, L.R., Charlton, M.P. and Augustine, G.J. (1993) The spatial distribution of calcium signals in squid presynaptic terminals. J. Physiol. (Cambridge), 472, 573-593.
21.3 MB High Res [AVI File]
2.9 MB [Quicktime Zip File]
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Localization of presynaptic Ca influx,
Squid giant synapse, high magnification.
Smith, S.J, Buchanan, J., Osses, L.R., Charlton, M.P. and Augustine, G.J. (1993) The spatial distribution of calcium signals in squid presynaptic terminals. J. Physiol. (Cambridge), 472, 573-593.
16.0 MB High Res [AVI File]
2.8 MB [Quicktime Zip File]
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Dendritic Filopodia in a Cultured Hippocampal Slice
Dailey , M.E. and Smith, S.J (1996) The dynamics of dendritic structure in developing hippocampal slices. J. Neurosci. 16: 2983-2994. [PDF]
MB High Res [AVI File]
3.5 MB [Quicktime Zip File]
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Dendritic Filopodia in a Cultured Hippocampal Slice
Dailey , M.E. and Smith, S.J (1996) The dynamics of dendritic structure in developing hippocampal slices. J. Neurosci. 16: 2983-2994. [PDF]
MB High Res [AVI File]
8.2 MB [Quicktime Zip File]
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Ca Responses to Visual Simulation
Measured in Larval Zebrafish in vivo
Niell, C.M and Smith, S.J (2005) Functional imaging reveals rapid development of visual response properties in the zebrafish tectum. Neuron 45: 941-951. [PDF]
MB High Res [AVI File]
632 KB [Quicktime Zip File]
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Mauthner Axon - Motoneuron Contact,
Embryonic Zebrafish Spinal Cord
Jontes, J.D., Buchanan, J. and Smith, S.J (2000)
Growth cone and dendrite dynamics in zebrafish embryos:
in vivo imaging of early events in synaptogenesis.
Nature Neuroscience 3: 231-237. [PDF]
MB High Res [AVI File]
3.2 MB [Quicktime Zip File]
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GFP-E-Cadherin in MDCK Cells + Nomarski DIC,
Low Magnification Time-Lapse
Adams, C.L., Chen, Y.T., Smith, S.J and Nelson, W.J. (1998) Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-Cadherin-green fluorescent protein. J. Cell Biol. 142: 1105-1119. [PDF]
MB High Res [AVI File]
2.4 MB [Quicktime Movie File]
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GFP-E-Cadherin at New Contact in MDCK Cells,
High Magnification Time-Lapse
Adams, C.L., Chen, Y.T., Smith, S.J and Nelson, W.J. (1998) Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-Cadherin-green fluorescent protein. J. Cell Biol. 142: 1105-1119. [PDF]
MB High Res [AVI File]
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Dendritic Filopodia in Hippocampal Cell Cultures,
11 and 27 Days in vivo
Ziv. N.E. and Smith, S.J (1996) Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron 17: 91-102. [PDF]
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