Array Tomography of Transgenic Mouse Somatosensory Cortex Layer 5B
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Reference: Micheva, K.D., and Smith, S.J (2007) Array tomography: A new tool for imaging the molecular architecture and ultrastructure of neural circuits. Neuron 55:25-36.
Green: Thy1-H-YFP (Layer 5B Neuron Subset); Red: Synapsin I (Synapses); Blue: DAPI (DNA in all nuclei).
Array Tomography of Amyloid Plaque in Cortex of Alzheimer Mouse
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Reference: Koffie, R.M., Meyer-Luehmann, M., Hashimoto, T., Adams, K.W., Mielke, M.L., Garcia-Alloza, M., Micheva, K.D., Smith, S.J, Kim, M.L., Lee, V.M., Hyman, B.T., and Spires-Jones, T.L. (2009) Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc. Natl. Acad. Sci., USA 106: 4012-7.
Array Tomography of Amyloid Plaque in Cortex of Deceased Alzheimer Human
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Reference: Work in progress - Nancy O’Rourke (Stanford), Virginia Lee and John Trojanowski (U. Penn.).
Red: Synapsin I; Green: Amyloid Beta; Blue: Tubulin; Pink: phospho-Tau; Gold: Thio-S staining; White: DAPI DNA.
Array Tomography of Transgenic Mouse Somatosensory Cortex Layer 5A
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mMos3_YRock8_L5b_YFP_1024_sH264ah.mov
Reference: Micheva, K.D., Busse, B.L., Weiler, N.C., O'Rourke, N., Smith, S.J (2010) Single-synapse analysis of a diverse synapse population: Proteomic imaging methods and markers. Neuron 68:639-653.
Green: Thy1-H-YFP (Layer 5B Neuron Subset). Larger spiny branches are dendrites; Very fine crossing filaments are axons.
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Machinery of Mind
(A 5-minute flight through mouse cortex)
QuickTime Downloads:
Machinery_of_Mind_SD.mov (1024x768, 694 MB)
Machinery_of_Mind_HD.mov (1920x1080, 1.24 GB)
Reference: Micheva, K.D., Busse, B.L., Weiler, N.C., O'Rourke, N., Smith, S.J (2010) Neuron 68:639-653.
Green: Thy1-H-YFP (Layer 5B Neuron Subset); Red: Synapsin I (Synapses); Blue: Tubulin (Dendrite, Axon Cores)
Musical Score: Catherine Rose Smith