Array Tomography of Transgenic Mouse Somatosensory Cortex Layer 5B

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C195HD_1024.mov

Reference: Micheva, K.D., and Smith, S.J (2007)  Array tomography: A new tool for imaging the molecular architecture and ultrastructure of neural circuits.  Neuron 55:25-36.

Green: Thy1-H-YFP (Layer 5B Neuron Subset); Red: Synapsin I (Synapses); Blue: DAPI (DNA in all nuclei).

Array Tomography of Amyloid Plaque in Cortex of Alzheimer Mouse

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Mouse Plaque 2 1022.mov

Reference: Koffie, R.M., Meyer-Luehmann, M., Hashimoto, T., Adams, K.W., Mielke, M.L., Garcia-Alloza, M., Micheva, K.D., Smith, S.J, Kim, M.L., Lee, V.M., Hyman, B.T., and Spires-Jones, T.L. (2009) Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.  Proc. Natl. Acad. Sci., USA 106: 4012-7.

Array Tomography of Amyloid Plaque in Cortex of Deceased Alzheimer Human

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Human_AD_Plaque.mov

Reference: Work in progress - Nancy O’Rourke (Stanford), Virginia Lee and John Trojanowski (U. Penn.).

Red: Synapsin I; Green: Amyloid Beta; Blue: Tubulin; Pink: phospho-Tau; Gold: Thio-S staining; White: DAPI DNA.

Array Tomography of Transgenic Mouse Somatosensory Cortex Layer 5A

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mMos3_YRock8_L5b_YFP_1024_sH264ah.mov

Reference: Micheva, K.D., Busse, B.L., Weiler, N.C., O'Rourke, N., Smith, S.J (2010) Single-synapse analysis of a diverse synapse population: Proteomic imaging methods and markers.  Neuron 68:639-653.

Green: Thy1-H-YFP (Layer 5B Neuron Subset).  Larger spiny branches are dendrites; Very fine crossing filaments are axons.

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