Microarray Technology

Stephen Smith designed this confocal laser scanner as part of a collaboration with Pat Brown, Dari Shalon and Noam Ziv that introduced the use of high-density arrays of cDNA spotted onto glass slides to measure simultaneously thousands of messenger RNA species. This prototype scanner read all arrays for approximately the first two years of the Brown lab's pioneering microarray science and served as the model for many later "home-made" and commercial microarray readers.

Stephen Smith was a consultant to Axon Instruments, Inc. and a co-inventor of the highly successful GenePix microarray reader.

Bibliography

Shalon, D., Smith, S. J and Brown, P.O. (1996) A DNA micro-array system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Research 6:639-645.

Osipchuk, Y., Dromaretsky, S., Roll, Y. and Smith, S.J (2003) High-efficiency, large field scanning microscope. US Patent #6,628,385. [PDF] (cover page)

Osipchuk, Y., Dromaretsky, S., Roll, Y. and Smith, S.J (2004) High-efficiency, large field scanning microscope. US Patent #6,833,916. [PDF] (cover page)

Home