Calcium Dynamics

Calcium ions couple cellular stimulus to response in virtually every type of cell. Such coupling usually involves rapid and spatially limited changes in intracellular calcium ion concentrations that press the limits of physiological measurement techniques. Moreover, many important Ca signaling events occur on temporal or spatial scales too fast or small for any direct measurement and thus requires exploration by modeling and computational simulation. The Smith laboratory has a long-standing interest in the dynamics and biophyical basis of intracellular Ca signaling.

Calcium Signaling Dynamics

Zucker, R.S. and Smith, S.J. (1979) Effect of TEA on light emission from aequorin-injected Aplysia in neurone soma. Brain Res. 164: 91-102. [Pubmed]

Smith, S.J. and Zucker, R.S. (1980) Aequorin response facilitation and intracellular calcium accumulation in molluscan neurones. J. Physiol. (Lond) 300: 167-196. [Pubmed]

Adams, D.J., Smith, S.J. and Thompson, S.H. (1980) Ionic currents in molluscan soma. Ann. Rev. Neurosci. 3:141-167. [PDF]

Smith, S.J. (1981) Excitability of gastropod neurons. Neurosci. Res. Prog. Bull. 119: 286-291.

Smith, S.J. (1981) Calcium regulation in gastropod nerve cell bodies. In: Molluscan Nerve Cells (eds. J. Koester and J.H. Byrne) Cold Spring Harbor Laboratory, pp. 81-91.

Charlton, M.P., Smith, S.J. and Zucker, R.S. (1982) Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse. J. Physiol. (Lond) 323: 173-193.

Smith, S.J., MacDermott, A.B. and Weight, F.F. (1983) Detection of intracellular calcium transients in sympathetic neurones using arsenazo III. Nature 304: 350-352.

Hoshi, T., Rothlein, J. and Smith, S.J. (1984) Facilitation of Ca channel currents in bovine adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA 81: 5871-5875. [PDF]

Boyle, M.B., Klein, M., Smith, S.J. and Kandel, E.R. (1984) Serotonin increases intracellular Ca transients in voltage-clamped sensory neurons of Aplysia californica. Proc. Natl. Acad. Sci. USA 81: 7642-7646. [PDF]

Smith, S.J., Augustine, G.A. and Charlton, M.P. (1985) Transmission at voltage-clamped giant synapse of the squid: evidence for cooperative calcium action in secretion of synaptic transmitter. Proc. Natl. Acad. Sci. USA 82: 622-625. [PDF]

Augustine, G.J., Charlton, M.P. and Smith, S.J. (1985) Calcium entry into voltage-clamped presynaptic terminals of squid. J. Physiol. (Lond) 367: 143-162.

Augustine, G.J., Charlton, M.P. and Smith, S.J. (1985) Calcium entry and transmitter release at voltage-clamped nerve terminals of squid. J. Physiol. (Lond) 367: 163-181.

Smith, S.J. (1985) Polychromator for recording optical absorbance changes from single cells. In: Optical Methods in Cell Physiology (eds. P. DeWeer and B. Salzberg) New York: John Wiley.

MacDermott, A.B., Mayer, M.L., Westbrook, G.L., Smith, S.J., and Barker, J.L. (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321: 519-522.

Smith, S.J., Charlton, M.P., and Augustine, G.J. (1986) The voltage-dependence of transmitter release. J. Physiol. ( Paris) 81(4): 332-339.

Smith, S.J. and Thompson, S.H. (1987) Slow membrane currents in bursting pace-maker neurones of Tritonia. J. Physiol. (Lond) 382: 425-448.

Hoshi, T. and Smith, S.J. (1987) Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells. J. Neurosci. 7: 571-580. [PDF]

Mayer, M.L., MacDermott, A.B., Westbrook, G.L., Smith, S.J. and Barker, J.L. (1987) Agonist- and voltage-gated calcium entry in mouse spinal cord neurons under voltage clamp measured using arsenazo III. J. Neurosci. 7: 3230-3244. [PDF]

Augustine, G.J., Charlton, M.P. and Smith, S.J. (1987) Ca action in synaptic transmitter release. Ann. Rev. Neurosci. 10: 633-693. [PDF]

Smith, S.J. (1987) Progress on LTP at hippocampal synapses: A post-synaptic Ca trigger for memory storage? Trends Neurosci. 10: 142-44.

Smith, S.J., Osses, L.R. and Augustine, G.J. (1988) Fura-2 imaging of localized calcium accumulation within squid 'giant' presynaptic terminal. In: Ion Channel Modulation (Grinnel, A.D., Armstrong, D.L. and Jackson, M.B., eds.), Plenum: New York. pp. 147-155.

Augustine, G.J., Charlton, M.P. and Smith, S.J. (1988) Toward a molecular understanding of synaptic transmitter release: Physiological clues from the squid giant synapse. In: Ion Channel Modulation (Grinnel, A.D., Armstrong, D.L. and Jackson, M.B., eds.), Plenum: New York. pp. 157-168.

Smith, S.J. and Augustine, G.J. (1988) Calcium ions, active zones and neurotransmitter release. Trends Neurosci. 11:458-464.

Augustine, G.J., Buchanan, J., Charlton, M.P., Osses, L.R. and Smith, S.J (1989). Fingering the trigger for neurotransmitter secretion: Studies on the calcium channels of squid giant presynaptic terminals. In: Secretion and Its Control ( Oxford, G. and Armstrong, C., Eds.), New York: The Rockefeller University Press, pp. 204-223.

Brehm, P., Lechleiter, J., Smith, S.J and Dunlap, K. (1989) Intercellular signalling as visualized by endogenous calcium-dependent bioluminescence. Neuron3: 191-198. [PDF]

Cornell-Bell, A.H., Finkbeiner, S.M., Cooper, M.S. and Smith, S.J (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signalling. Science 247: 470-473.

Goldman, R.S., Finkbeiner, S.M. and Smith, S.J (1991) Endothelin induces a sustained rise in intracellular calcium in hippocampal astrocytes. Neurosci. Lett. 123: 4-8.

Dani, J.W., Chernjavsky, A, and Smith, S.J. (1992) Neuronal activity triggers Ca waves in hippocampal astrocyte networks. Neuron 8: 429-440. [PDF]

Smith, S.J., Do astrocytes process neural information? (1992) Prog. in Brain Res. 94, 119-136. [PDF]

Reist, N.E. and Smith, S.J. (1992) Neurally-evoked calcium transients in terminal Schwann cells at the neuromuscular junction. Proc. Natl. Acad. Sci., U.S.A. 89, 7625-7629. [PDF]

Smith, S.J, Buchanan, J., Osses, L.R., Charlton, M.P. and Augustine, G.J. (1993) The spatial distribution of calcium signals in squid presynaptic terminals. J. Physiol. ( Cambridge),472, 573-593.

Dailey , M.E. and Smith, S.J (1994) Spontaneous Ca2+ transients in developing hippocampal pyramidal cells. J. Neurobiol. 25: 243-251. [PDF]

Smith, S.J (1994) Neuromodulatory Astrocytes. Current Biology 4: 807-810. [PDF]

Dani, J.W. and Smith, S.J (1995) The triggering of astrocytic calcium waves by NMDA-induced neuronal activation. Ciba Foundation Symposium 188: 195-209.

Wong, R. O. L., Chernjavsky, A., Smith, S.J and Shatz, C.J. (1995) Early functional neural networks in the developing retina. Nature 374: 716-718. [PDF]

Niell, C.M. and Smith, S.J (2004) Live optical imaging of nervous system development. Ann. Rev. Physiol., 66 : 771-798. [PDF]

Niell, C.M and Smith, S.J (2005) Functional imaging reveals rapid development of visual response properties in the zebrafish tectum. Neuron 45: 941-951. [PDF]
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